Mr Prescott was born at Salem, Massachusetts, May 4, 1796. His father, a lawyer of rising reputation, then thirty-four years of age, removed his family to Boston in 1808. At the age of fifteen William entered Harvard College. While engaged in a boyish frolic one day during his junior year a large hard piece of bread, thrown probably at random, struck full in his left eye, forever depriving him of its use. Pursuing his studies with his wonted cheerfulness, he graduated in 1814, and entered upon the study of law in his father’s office. In 1815 a rheumatic inflammation settled in his right eye, now his sole dependence, causing him much pain and anxiety. A change of climate having been determined upon, he embarked for the Azores, on a visit to his grandfather Hickling, then United States consul at Saint Michael. There he remained about six months, confined the greater part of the time to a dark room. In April 1816 he embarked for London, crossed to Paris, made the usual Italian tour, and the following year, his eye becoming worse, he returned home. But hope for the restoration of his sight still lingered, and the marvellous buoyancy of his spirits never deserted him. A devoted sister cheered the long hours of his solitude by readings from his favorite authors. A literary venture made at this time in a contribution to the North American Review failed; his manuscript was returned, and his sister, alone in the secret, was enjoined to silence.
Leaving his darkened chamber and mingling again with society, of which he was ever a bright ornament, he became attached to a daughter of Thomas C. Amory, a Boston merchant, whom he married on his twenty-fourth birthday.