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searching for the particular poison suggested by the circumstances, but should search, as a matter of routine, for all the various classes of scheduled poisons, including not only the other vegetable alkalis but also the metallic poisons. The analysis was made with great care, and I can confidently state that every possibility was eliminated, except that of poisoning by muscarine. This poison, which was present in very considerable quantities, was unmistakably identified, while the symptoms and postmortem appearances, as reported by the witnesses, were indubitably consistent with this form of poisoning. I may add that preparations of the viscera, vomit, etc. , and the unconsumed part of the dish of fungi have been preserved untouched, as is my invariable custom in such cases, so as to be available for future reference or analysis in case of any further question being raised. Humanly speaking, however, you may rely absolutely on the accuracy of my results. With regard to the composition of the dish, I find, on referring to my notes, that this consisted of fungi exhibiting the structural features of Amanita, stewed whole in a preparation of beef broth, flavoured with garlic and pot-vegetables. Your further question displays a slight misapprehension. The isolation of muscarine itself in a pure state from the fungus would be a chemical experiment of considerable difficulty, and has, so far as I know, been accomplished only by two men, Harnack and Nothnagel; their results have not, I believe, received confirmation as yet. Choline aurichloride and muscarine aurichloride have been