"Whether germinal variations," remarked Dr. R.J. Ryle at a Conference on Feeble-mindedness (British Medical Journal, October 3, 1911), "be expressed by cleft palate, cataract, or cerebral deficiency of the pyramidal cells in the brain cortex, they may be produced, and, when once produced, they are reproduced as readily as the perfected structure of the face or eye or brain, if the gametes which contain these potentialities unite to form the ovum. But Nature is not only the producer. Given a fair field and no favour, natural selection would leave no problem of the unfit to perplex the mind of man who looks before and after. This we know cannot be, and we know, too, that we have no longer the excuse of ignorance to cover the neglect of the new duties which belong to the present epoch of civilization. We know now that we have to deal with a growing group in our community who demand permanent care and control as well for their own sakes as for the welfare of the community. All are now agreed on the general principle of segregation, but it is true that something more than this should be forthcoming.