It is inherent in the peculiar character of the Method of Difference, that the nature of the combinations which it requires is much more strictly defined than in the Method of Agreement. The two instances which are to be compared with one another must be exactly similar, in all circumstances except the one which we are attempting to investigate: they must be in the relation of A B C and B C, or of a b c and b c. It is true that this similarity of circumstances needs not extend to such as are already known to be immaterial to the result. And in the case of most phenomena we learn at once, from the commonest experience, that most of the co-existent phenomena of the universe may be either present or absent without affecting the given phenomenon; or, if present, are present indifferently when the phenomenon does not happen and when it does. Still, even limiting the identity which is required between the two instances, A B C and B C, to such circumstances as are not already known to be indifferent, it is very seldom that nature affords two instances, of which we can be assured that they stand in this precise relation to one another. In the spontaneous operations of nature there is generally such complication and such obscurity, they are mostly either on so overwhelmingly large or on so inaccessibly minute a scale, we are so ignorant of a great part of the facts which really take place, and even those of which we are not ignorant are so multitudinous, and therefore so seldom exactly alike in any two cases, that a spontaneous experiment, of the kind required by the Method of Difference, is commonly not to be found. When, on the contrary, we obtain a phenomenon by an artificial experiment, a pair of instances such as the method requires is obtained almost as a matter of course, provided the process does not last a long time. A certain state of surrounding circumstances existed before we commenced the experiment; this is B C. We then introduce A; say, for instance, by merely bringing an object from another part of the room, before there has been time for any change in the other elements. It is, in short (as M. Comté observes), the very nature of an experiment, to introduce into the pre-existing state of circumstances a change perfectly definite. We choose a previous state of things with which we are well acquainted, so that no unforeseen alteration in that state is likely to pass unobserved; and into this we introduce, as rapidly as possible, [pg 282] the phenomenon which we wish to study; so that in general we are entitled to feel complete assurance that the pre-existing state, and the state which we have produced, differ in nothing except the presence or absence of that phenomenon. If a bird is taken from a cage, and instantly plunged into carbonic acid gas, the experimentalist may be fully assured (at all events after one or two repetitions) that no circumstance capable of causing suffocation had supervened in the interim, except the change from immersion in the atmosphere to immersion in carbonic acid gas. There is one doubt, indeed, which may remain in some cases of this description; the effect may have been produced not by the change, but by the means employed to produce the change. The possibility, however, of this last supposition generally admits of being conclusively tested by other experiments. It thus appears that in the study of the various kinds of phenomena which we can, by our voluntary agency, modify or control, we can in general satisfy the requisitions of the Method of Difference; but that by the spontaneous operations of nature those requisitions are seldom fulfilled.
The reverse of this is the case with the Method of Agreement. We do not here require instances of so special and determinate a kind. Any instances whatever, in which nature presents us with a phenomenon, may be examined for the purposes of this method; and if all such instances agree in any thing, a conclusion of considerable value is already attained. We can seldom, indeed, be sure that the one point of agreement is the only one; but this ignorance does not, as in the Method of Difference, vitiate the conclusion; the certainty of the result, as far as it goes, is not affected. We have ascertained one invariable antecedent or consequent, however many other invariable antecedents or consequents may still remain unascertained. If A B C, A D E, A F G, are all equally followed by a, then a is an invariable consequent of A. If a b c, a d e, a f g, all number A