When an effect results from the union of many causes, the share which each has in the determination of the effect can not in general be great, and the effect is not likely, even in its presence or absence, still less in its variations, to follow, even approximately, any one of the causes. Recovery from a disease is an event to which, in every case, many influences must concur. Mercury may be one such influence; but from the very fact that there are many other such, it will necessarily happen that although mercury is administered, the patient, for want of other concurring influences, will often not recover, and that he often will recover when it is not administered, the other favorable influences being sufficiently powerful without it. Neither, therefore, will the instances of recovery agree in the administration of mercury, nor will the instances of failure agree in its non-administration. It is much if, by multiplied and accurate returns from hospitals and the like, we can collect that there are rather more recoveries and rather fewer failures when mercury is administered than when it is not; a result of very secondary value even as a guide to practice, and almost worthless as a contribution to the theory of the subject.4
§ 8. The inapplicability of the method of simple observation to ascertain the conditions of effects dependent on many concurring causes, being thus recognized, we shall next inquire whether any greater benefit can be expected from the other branch of the a posteriori method, that which proceeds by directly trying different combinations of causes, either artificially produced or found in nature, and taking notice what is their effect; as, for example, by actually trying the effect of mercury in as many different circumstances as possible. This method differs from the one which we have just examined in turning our attention directly to the causes or agents, instead of turning it to the effect, recovery from the disease. And since, as a general rule, the effects of causes are far more accessible to our study than the causes of effects, it is natural to think that this method has a much better chance of proving successful than the former.
The method now under consideration is called the Empirical Method; and in order to estimate it fairly, we must suppose it to be completely, not incompletely, empirical. We must exclude from it every thing which partakes of the nature not of an experimental but of a deductive operation. If, for instance, we try experiments with mercury upon a person in health, in order to ascertain the general laws of its action upon the human body, and then reason from these laws to determine how it will act upon persons affected with a particular disease, this may be a really effectual method; but this is deduction. The experimental method does not derive the law of a complex case from the simpler laws which conspire to produce it, but makes its experiments directly upon the complex case. We must make entire abstraction of all knowledge of the simpler tendencies, the modi operandi of mercury in detail. Our experimentation must aim at obtaining a direct answer to the specific question, Does or does not mercury tend to cure the particular disease?
Let us see, therefore, how far the case admits of the observance of those rules of experimentation which it is found necessary to observe in other cases. When we devise an experiment to ascertain the effect of a given agent, there are certain precautions which we never, if we can help it, omit. In the first place, we introduce the agent into the midst of a set of circumstances which we have exactly ascertained. It needs hardly be remarked how far this condition is from being realized in any case connected with the phenomena of life; how far we are from knowing what are all the circumstances which pre-exist in any instance in which mercury is administered to a living being. This difficulty, however, though insuperable in [pg 323] most cases, may not be so in all; there are sometimes concurrences of many causes, in which we yet know accurately what the causes are. Moreover, the difficulty may be attenuated by sufficient multiplication of experiments, in circumstances rendering it improbable that any of the unknown causes should exist in them all. But when we have got clear of this obstacle, we encounter another still more serious. In other cases, when