Thereupon, taking as my ground of inference the simplest and best known of the principles that have been implanted in our minds by nature, I considered the chief differences that could possibly subsist between the magnitudes, and figures, and situations of bodies insensible on account of their smallness alone, and what sensible effects could be produced by their various modes of coming into contact; and afterwards, when I found like effects in the bodies that we perceive by our senses, I judged that they could have been thus produced, especially since no other mode of explaining them could be devised. And in this matter the example of several bodies made by art was of great service to me: for I recognize no difference between these and natural bodies beyond this, that the effects of machines depend for the most part on the agency of certain instruments, which, as they must bear some proportion to the hands of those who make them, are always so large that their figures and motions can be seen; in place of which, the effects of natural bodies almost always depend upon certain organs so minute as to escape our senses.