inquiry; and the theoretical constructions which prevail in such sciences are neither unbiased reports of the actual constitution of an external reality, nor yet arbitrary constructions of fancy. These constructions in fact resemble in a measure those which M. Poincaré in this book has analyzed in the case of geometry. They are constructions molded, but not predetermined in their details, by experience. We report facts; we let the facts speak; but we, as we investigate, in the popular phrase, 'talk back' to the facts. We interpret as well as report. Man is not merely made for science, but science is made for man. It expresses his deepest intellectual needs, as well as his careful observations. It is an effort to bring internal meanings into harmony with external verifications. It attempts therefore to control, as well as to submit, to conceive with rational unity, as well as to accept data. Its arts are those directed towards self-possession as well as towards an imitation of the outer reality which we find. It seeks therefore a disciplined freedom of thought. The discipline is as essential as the freedom; but the latter has also its place. The theories of science are human, as well as objective, internally rational, as well as (when that is possible) subject to external tests.
In a field very different from that of the historical sciences, namely, in a science of observation and of experiment, which is at the same time an organic science, I have been led in the course of some study of the history of certain researches to notice the existence of a theoretical conception which has proved extremely fruitful in guiding research, but which apparently resembles in a measure the type of hypotheses of which M. Poincaré speaks when he characterizes the principles of mechanics and of the theory of energy. I venture to call attention here to this conception, which seems to me to illustrate M. Poincaré's view of the functions of hypothesis in scientific work.
The modern science of pathology is usually regarded as dating from the earlier researches of Virchow, whose 'Cellular Pathology' was the outcome of a very careful and elaborate induction. Virchow, himself, felt a strong aversion to mere speculation. He endeavored to keep close to observation, and to relieve medical science from the control of fantastic theories, such as those of the Naturphilosophen had been. Yet Virchow's researches were, as early as 1847, or still earlier, already under the guidance of a theoretical presupposition which he himself states as follows: "We have learned to recognize," he says, "that diseases are not autonomous organisms, that they are no entities that have entered into the body, that they are no parasites which take root in the body, but that they merely show us the course of the vital processes under altered conditions" ('dasz sie nur Ablauf der Lebenserscheinungen unter veränderten Bedingungen darstellen').
The enormous importance of this theoretical presupposition for all the early successes of modern pathological investigation is generally recognized by the experts. I do not doubt this opinion. It appears to be a commonplace of the history of this science. But in Virchow's later years this very presupposition seemed to some of his contemporaries to be called in question by the successes of recent bacteriology. The question arose whether the theoretical foundations of Virchow's pathology had not been set aside. And in fact the theory of the parasitical origin of a vast number of diseased conditions has indeed come upon an empirical basis to be generally recognized. Yet to the end of his own career Virchow stoutly maintained that in all its essential significance his own fundamental principle remained quite untouched by the newer discoveries. And, as a fact, this view could indeed be maintained. For if diseases proved to be the consequences of the presence of parasites, the diseases themselves, so far as they belonged to the diseased organism, were still not the parasites, but were, as before, the reaction of the organism to the veränderte Bedingungen which the presence of the parasites entailed. So Virchow could well insist. And if the famous principle in question is only stated with sufficient generality, it amounts simply to saying that if a disease involves a change in an organism, and if this change is subject to law at all, then the nature of the organism and the reaction of the