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APPENDIX D

For a while, this hypothesis was of service in the development of genetics; some students even began to forget that it was a hypothesis, and to talk as if it were a fact. But the exhaustive tests of experimental breeding of plants and animals have long caused most of the advanced students of genetics to drop this simple hypothesis.

In its place stands the factorial hypothesis, evolved by workers in America, England, and France at about the same time. As explained in Chapter V, this hypothesis carries the assumption that every visible character is due to the effects of not one but many factors in the germ-cell.

In addition to these fundamentals, there are numerous extensions and corollaries, some of them of a highly speculative nature. The reader who is interested in pursuing the subject farther must turn to one of the text-books on Mendelism.

In plant-breeding a good deal of progress has been made in the exact study of Mendelian heredity; in animal breeding, somewhat less; in human heredity, very little. The reason is obvious: that experiments can not be made in man, and students must depend on the results of such matings as they can find; that only a very few offspring result from each mating; and that generations are so long that no one observer can have more than a few under his eyes. These difficulties make Mendelian research in man a very slow and uncertain matter.

Altogether, it is probable that something like a hundred characters in man have been pointed out as inherited in Mendelian fashion. A large part of these are pathological conditions or rare abnormalities.

But the present writers can not accept most of these cases. It has been pointed out in Chapter V that there are good reasons for doubting that

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